PROTAMINE SULFATE HERRING
protamine sulfate from salmon cell*culture tested
CAS: 53597-25-4
Molecular Formula:
PROTAMINE SULFATE HERRING - Names and Identifiers
PROTAMINE SULFATE HERRING - Physico-chemical Properties
| Solubility | H2O: 10mg/mL |
| Appearance | amorphous powder |
| Color | white |
| Merck | 13,8417 |
| Storage Condition | Store at RT. |
| Use | Anti-heparin drug for bleeding caused by excessive heparin injection |
PROTAMINE SULFATE HERRING - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | VO9470000 |
| FLUKA BRAND F CODES | 21-10 |
| Toxicity | LD50 i.v. in rats: 75 mg/kg (Starbuck) |
PROTAMINE SULFATE HERRING - Reference
| Reference Show more | 1. Wang Xuan, Hu Zhongqiu, Yuan Yahong, etc. Antibacterial effect of natural bacteriostats on Ruz's conjugating yeast [J]. Modern food science and technology, 2018, 34(10):100-108. 2. Chen Han, liantin, du Far East, Chen Cheng, Ma Bao. Preparation and quality evaluation of puerarin liposome thermosensitive gel for nasal use [J]. Chemical Technology, 2020,28(05):41-46. 3. Lu, Dai, et al. "A critical factor for quantifying proteins in unmodified gold nanoparticles-based aptasensing: The effect of pH." Chemosensors 8.4 (2020): 98.https://doi.org/10.3390/chemosensors8040098 4. [IF=5.833] Wang Yanying et al."A carbon dot-based ratiometric fluorometric and colorimetric method for determination of ascorbic acid and of the activity of ascorbic acid oxidase."Microchim Acta. 2019 Apr;186(4):1-10 |
PROTAMINE SULFATE HERRING - Nature
Open Data Verified Data
sulfate of a basic protein extracted from a suitable fish fresh mature sperm. This product is white or white-like powder; The aqueous solution shows acidic reaction to litmus paper. Slightly soluble in water, insoluble in ethanol or ether. Heating does not solidify, dilute ammonia can make its precipitation. Protamine is a strong basic protein with a strong positive charge. It can rapidly bind to the acidic groups necessary for the maintenance of anticoagulant activity in heparin molecules, which makes heparin lose anticoagulant activity. Because heparin is a sulfate ester of mucopolysaccharide, which is strongly acidic, its molecule has a negative charge in the physiological category. It is generally believed that the anticoagulant effect of heparin is related to its negative charge, when this negative charge is neutralized by protamine, the pharmacological effect is lost. Its molecular weight is small, which contains arginine, up to more than 80%.
Last Update：2024-01-02 23:10:35
PROTAMINE SULFATE HERRING - Use
Open Data Verified Data
- Anti-heparin drug.
- The preparation injection is an isotonic sterile aqueous solution prepared by adding sodium chloride to protamine sulfate. Colorless clear liquid.
- the usage and dose must be given intravenously. The effect of heparin is terminated with protamine in an amount equivalent to the dose of heparin used last time. Or based on the results of the determination of coagulation time, but not more than 50mg at a time. Heparin is metabolized rapidly in the body, so the longer the time interval after injection, the smaller the dose of protamine required. Also used for hemoptysis and other spontaneous bleeding. Intravenous infusion, 5~8mg per kilogram of body weight per day, divided into two intervals of 5~6 hours application, each time with normal saline 300 ~ 500mL dilution, continuous application of no more than 3 days.
Last Update：2022-01-01 11:12:12
PROTAMINE SULFATE HERRING - Safety
Open Data Verified Data
- not excessive application; Injection must be slow, reduce the incidence of hypotension; Allergic reactions to fish allergy report; Disinfection injection supplies, do not use alkaline substances.
- it was sealed and kept in a cool dark place.
Last Update：2022-01-01 11:12:12
PROTAMINE SULFATE HERRING - Reference Information
| uses | antiheparin drugs are used for bleeding caused by excessive heparin injection. protarin sulfate can not only be used as a reagent, but also as a specific drug for antagonizing heparin, as an extension of insulin for the treatment of diabetes and male infertility. In addition, it can be used as a preservative and food additive. Biochemical research |
Last Update：2024-04-09 21:54:55
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Product Name: Protamine sulfate from Salmon sperm Visit Supplier Webpage Request for quotationCAS: 53597-25-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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